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Final analysis of quality-of-life assessment in lymphoma patients who underwent high-dose chemotherapy and autologous stem cell transplant (HDC ASCT) using first validated, translated Arabic form of FACT-BMT version (4): Single-institution experience



Article type: Published article

Abstract

Background: Quality of life (QOL) is growing in importance as an assessment measure following HDC ASCT. Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) from English has been translated into several languages. We report our translated and validated first Arabic FACT-BMT. Methods: Study was approved by the Institutional Research Advisory Council. The Arabic translation followed the standard Functional Assessment of Chronic Illness Therapy (FACIT.org) translation methodology (permission was obtained). Provisional Arabic FACT-BMT was pre-tested and then statistically validated. Results: 108 relapsed /refractory lymphoma patients underwent HDC ASCT. Salvage protocol was (ESHAP) +/- rituximab and BEAM protocol as HDC. Diagnosis was Hodgkin lymphoma 69%; non-Hodgkin lymphoma 31%.Males 63% and females 37%. Reliability coefficients Cronbach’s alpha for internal consistency was 0.90, Intraclass correlation coefficient for internal consistency 0.89, agreements 0.86 all were excellent. 31 (30%), 25 (24.5%), 30 (29.4%) and 16 (15%) patients were interviewed 3-12 , 12-24,24-60 or > 60 months respectively from HDC ASCT. 93% were educated. Patients have high scores in all domains of quality of life including physical, social, emotional and functional well-being, indicating that most patients were leading a normal life. Twenty-six percent of patients were concerned about their ability to have children post-transplant. We found no difference in physical wellbeing, social wellbeing, functional wellbeing, and BMT domain in patients < 30 or > 30 years or male vs female. The score of emotional wellbeing domain for patients < 30 years was significantly lower than the score achieved by > 30 years patients (p-value=0.02). Conclusions: Our data reports the first translated and validated Arabic version of FACT-BMT. This is likely to help large number of Arabic speaking patients, not only in the Middle East and Arab countries, but also in Europe and North America. Most of our patients enjoyed a good quality of life post HDC-ASCT.


Full citation

Soudy, H., et al., Final analysis of quality-of-life assessment in lymphoma patients who underwent high-dose chemotherapy and autologous stem cell transplant (HDC ASCT) using first validated, translated Arabic form of FACT-BMT version (4): Single-institut


Methodology

Methods Condition Gender Age Country Setting Sample size
relapsed /refractory lymphoma patients Both Saudi Arabia
Healthcare Facility 108

Number of items

50 items

Training

Measure does not require training

Required time

6-30 min






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Articles last updated: June 2019